Itsuno from the start had a concrete vision of the game: Three playable characters, Nero as the protagonist, and the game starting from the loss of his right arm. Itsuno had been working on the game since after DMC4:SE was finished, and the full development team was formed in 2015.

The game had been in development since at least 2014, one year before the Devil May Cry 4: Special Edition had been released. Because we had these two sides mixing, it was like alright, we’re going to make Devil May Cry 5 – it’s not going to be a sequel to DmC, but we definitely want to do what we can to take what we learned from that game too.'

We had these people that didn’t work on DmC and people that did. So… when it came time to make a new game, we said, alright, let’s make Devil May Cry 5. Itsuno even remarked, 'I was really pumped up to do it, and then that didn’t happen. However, in contrast to Langdon's comments, Itsuno himself has gone on record saying he 'really wanted to make a DmC: Devil May Cry 2”. In the words of Langdon, Itsuno told Capcom that he'd stay if they let him do a Devil May Cry game the way he wanted to do it. Langdon stated that Itsuno had a 'wishlist', and Devil May Cry was at the top of it, Itsuno also stated in an interview that at one point he thought about making a new Dragon's Dogma game instead of a ' Devil May Cry 5', which could potentially be linked to this whole situation. According to Reuben Langdon, Hideaki Itsuno wanted to leave Capcom after DmC: Devil May Cry, stating that he was not happy and was ready to put in his resignation, however, Capcom didn't want him to leave and asked Itsuno what would make him stay in the company.

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